Evaluation of C-Reactive Protein, Some Interleukins, Trace Elements and Immunoglobulin Level in Preeclamptic Women Attending Federal Teaching Hospital, Owerri .

Abstract

Along with bleeding and infection, preeclampsia is one of the fatal trifecta of pregnancy complications that significantly increases maternal morbidity and mortality. The purpose of the study was to measure the levels of immunoglobulin, trace elements, C-reactive protein, and certain interleukins in preeclamptic women undergoing treatment at the Federal Teaching Hospital in Owerri, Imo state. About 50 preeclamptic individuals, 50 hypertensive pregnant women, and 50 seemingly healthy pregnant women made up the test group, which also included 50 control subjects. Standard techniques were used to determine the individuals' serum levels of immunoglobulins (IgA and IgM), interleukin, zinc, magnesium, iron, and C-reactive protein. SPSS version 27 was used to analyse the test outcomes. Preeclampsia women had significantly higher mean values of CRP (50.04±1.77) mg/L, TNF-alpha (29.84±2.25)pg/mL, IL-6 (40.08±2.44)pg/mL, Zn (22.14±1.95) µmol/L, and Fe (185.56±9.47) µg/dL than control (p=0.000, p=0.000, p=0.000, and p=0.000). In preeclamptic women, the mean IgA level (293.78±13.00) mg/dl was considerably lower (p=0.000) than in the control group. When comparing preeclamptic women to control, there was no significant difference (p=0.316 and p=0.517) in the mean values of Mg (0.87±0.15)mmol/l and IgM (112.66±9.32) mg/dl. Preeclamptic women had significantly higher mean values of CRP (50.04±1.77) mg/L, TNF-alpha (29.84±2.25) pg/mL, and Zn (22.14±1.95) µmol/L than control (p=0.000, p=0.000, p=0.000, and p=0.000). When comparing hypertensive pregnant women to the control group, the mean values of Fe (185.56±9.47)µg/dL and IgM (112.66±9.32) mg/dl were considerably lower (p=0.000 and p=0.000), respectively.When comparing preeclamptic women to the control group, there was no statistically significant difference (p=0.290 and p=0.286) in the mean values of IgA (293.78±13.00) mmol/l, mg (0.87±0.15) mmol/l, and IL-6 (40.08±2.44) pg/ml.In the preeclamptic group, there was a substantial positive connection (p<0.05) between magnesium and TNF-alpha.Iron and zinc, however, did not significantly correlate with a few immunological markers in the preeclamptic group (p>0.05). Elevations of C-reactive protein, TNF-alpha, IL-6, zinc, and iron have been linked to preeclampsia.IgA levels are lowered in patients with the condition, but there is no discernible correlation with IgM levels.In preeclamptic women, there was a noteworthy positive correlation observed between magnesium and TNF-alpha.